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KMID : 0385220050150010030
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Korean Journal of Gerontology
2005 Volume.15 No. 1 p.30 ~ p.42
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Implications of Oxidative and Inflammatory Stress in Alzheimers Disease
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Seo Young-Joon
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Abstract
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Oxidative stress induced by reactive oxygen intermediates (ROIs) has been considered as a major cause of cellular injuries in a variety of neurodegenerative disorders including Alzheimer’s disease (AD). Inflammatory as well as oxidative damage has been implicated in pathogenesis and/or progression of AD, and non-steroidal anti-inflammatory drugs have been reported to have beneficial effects in the treatment or prevention of this disease. b-Amyloid peptide (Ab) is considered to be responsible for the formation of senile plaques that accumulate in the brains of patients with AD. Several lines of evidence suggest that Ab-induced cytotoxicity is mediated through generation of ROIs and dysregulation of the normal inflammatory processes. Recently, considerable attention has been focused on identifying naturally occuring antioxidants that are able to reduce excess ROIs, thereby protecting against oxidative and inflammatory cell death induced by Ab. The understanding of intracellular signaling cascades in response to Ab-induced apoptosis and their modulation by natural antioxidant substances derived from dietary plants will pave the way to developing a new therapeutic strategy for the prevention and/or treatment of AD.
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KEYWORD
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Alzheimers disease, apoptosis, b-amyloid, inflammation, oxidative stress, phytochemicals
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